Journal article
Prominent contribution of L-type ca 2 channels to cutaneous neurovascular transmission that is revealed after spinal cord injury augments vasoconstriction
HA Dera, MD Habgood, JB Furness, JA Brock
American Journal of Physiology Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 2012
Abstract
In patients with spinal cord injury (SCI), somatosympathetic reflexes produce exaggerated decreases in skin blood flow below the lesion. This hypoperfusion appears to result from an increased responsiveness of cutaneous arterial vessels to neural activation. Here we investigated the mechanisms that underlie SCI-induced enhancement of neurovascular transmission in a cutaneous vessel, the rat tail artery. Isometric contractions of arterial segments from T11 spinal cord transected and sham-operated rats were compared 6 wk postoperatively. SCI more than doubled the amplitudes of contractions of arteries in response to moderate frequencies of nerve stimulation (0.1 to 1 Hz). In arteries from SCI ..
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Grants
Awarded by Victorian Neurotrauma Initiative
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The research was supported by Program Grant DP174 from the Victorian Neurotrauma Initiative. J. A. Brock was supported by Fellowship Grant 350904 from the National Health and Medical Research Council of Australia. H. Al Dera was supported by a postgraduate studentship from King Saud Bin Abdulaziz University for Health Science, College of Medicine (Riyadh, Saudi Arabia).